Exposure to adverse childhood experiences (ACEs) in young children affects the developing brain in ways that may impact behavior, cognitive development and physical health. As research uncovers greater knowledge and understanding of how ACEs can modify the brain, the need to implement practices that counterbalance the influence of the stress response is key to effective interventions. This module explores the impact of ACEs on the brain and offers strategies that incorporate brain-based approaches to enable more positive outcomes for young children who have experienced ACEs. Just over 25 percent of Kentucky’s children have experienced multiple ACEs. Prolonged exposure to stress and trauma can impact a child’s long-term physical and mental health, which can have serious implications for the nation’s schools, businesses, prisons, and health care system.Review all materials.